Current studies

The ALIA study (Antidepressant and Lithium Augmentation) is a pharmacogenetic study on the response prediction of lithium augmentation in unipolar depression. It is investigating whether there are genetic variants that lead to better or worse response to lithium augmentation.
Lithium augmentation is the addition of lithium salts to an antidepressant that has not been sufficiently effective alone. The efficacy of lithium augmentation in treatment-resistant depression is well established and is an approved treatment for depression. The aim of the study is to identify genetic markers that have predictive power for response to lithium augmentation (so-called response predictors). Knowledge of such factors could be incorporated into treatment decisions in the future and help improve therapy for depression. We offer patients who have not responded adequately to therapy with an antidepressant and are interested in participating in this scientific study the opportunity for treatment in the university outpatient clinic of the Department of Psychiatry and Psychotherapy of the Charité Campus Mitte.

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The "Star*Immun" study is a clinical observational study. It focuses on the scientific investigation of the relationship between depressive symptoms, neuroimmunological parameters, and experienced discrimination and minority stress. A comparison is made between sexual and gender minority populations and heterosexual cis people. Methodically, questionnaires as well as the examination of blood, saliva and hair samples are used. The aim is to better understand the development of depressive symptoms in marginalized people, and, in particular, to derive prevention strategies.

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The OASIS-D study (Patient Characteristics, Validity of Clinical Diagnoses and Outcomes Associated with Suicidality in Inpatients with Symptoms of Depression) will examine male and female inpatients aged 18 to 75 years with any form of unipolar depressive episode (patient population 1) admitted at study inclusion over a 6-month period, clinical diagnosis of moderate or severe unipolar depressive episode and existing suicidality who agree to participate in a prospective study (patient population 2), and research interview-validated moderate or severe unipolar depressive episode and suicidality followed up for 6 months (patient population 3). The aim of the study is to characterize the remission or recurrence of suicidal symptoms in the context of a depressive episode. The results are expected to help improve the understanding of the development of the disease, the further development of symptoms, and to find first evidence for effective interventions.

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